The use of canine models of inherited retinal degeneration to test novel therapeutic approaches

被引：39

作者：

Beltran, William A. ^{[1
]}

机构：

[1] Univ Penn, Sch Vet Med, Sect Ophthalmol, Philadelphia, PA 19104 USA

来源：

VETERINARY OPHTHALMOLOGY | 2009年 / 12卷 / 03期

关键词：

canine; degeneration; gene therapy; model; neuroprotection; retina; CILIARY NEUROTROPHIC FACTOR; LEBER CONGENITAL AMAUROSIS; MEDIATED GENE-TRANSFER; ROD-CONE DEGENERATION; DOMINANT RETINITIS-PIGMENTOSA; CALCIUM-CHANNEL BLOCKER; PLASMA-LIPID ABNORMALITIES; VITAMIN-A TREATMENT; NULL MUTATION DOG; D-CIS-DILTIAZEM;

D O I：

10.1111/j.1463-5224.2009.00694.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Inherited retinal degenerations (RDs) are a common cause of blindness in dogs and in humans. Over the past two decades numerous genes causally associated with these diseases have been identified and several canine models have been used to improve our understanding of the molecular mechanisms of RDs, as well as to test the proof of principle and safety of novel therapies. This review briefly summarizes the drug delivery approaches and therapeutic strategies that have been and are currently tested in dogs, with a particular emphasis on corrective gene therapy, and retinal neuroprotection.

引用

页码：192 / 204

页数：13

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