Flagellar biosynthesis in silico: Building quantitative models of regulatory networks

被引：3

作者：

Herrgard, MJ ^{[1
]}

Palsson, BO ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

来源：

CELL | 2004年 / 117卷 / 06期

关键词：

D O I：

10.1016/j.cell.2004.05.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Cell, Kalir and Alon (2004) describe the construction of an in silico model for the regulatory network responsible for the control of flagellar biosynthesis in E. coli based on quantitative gene expression data. They show how the model can be used as a quantitative blueprint to design genetic modifications with predictable influence on the dynamics of the system. The work by Kalir and Alon (2004) provides a general approach for building detailed models of transcriptional regulatory networks.

引用

页码：689 / 690

页数：2

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