NMR spectroscopy and imaging of the neonatal brain

被引：8

作者：

Cooper, CE

Wyatt, JS

机构：

[1] Univ Essex, Dept Biol Sci, Colchester CO4 3SQ, Essex, England

[2] UCL Royal Free & Univ Coll Med Sch, Dept Paediat, Rayne Inst, London WC1E 6JJ, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2000年 / 28卷

关键词：

hypoxia-ischaemia; mitochondria; MRI; MRS; neonate;

D O I：

10.1042/bst0280121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnetic resonance spectroscopy and imaging provide unique information about the brain to the biochemist and the clinician. In particular, the ability to image metabolites other than water and to get detailed information about dynamic cellular processes (such as blood flow, blood oxygenation and cell swelling) is leading to many new insights into brain function and dysfunction. This review describes the use of old and new NMR techniques which demonstrate that mitochondrial dysfunction plays an important role in the cell death that occurs following an hypoxic-ischaemic insult to the neonatal brain.

引用

收藏

页码：121 / 126

页数：6

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