Common Themes in the Design and Function of Bacterial Effectors

被引：255

作者：

Galan, Jorge E. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

来源：

CELL HOST & MICROBE | 2009年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

E3 UBIQUITIN LIGASES; PROTEIN-TYROSINE-PHOSPHATASE; ENTERICA SEROVAR TYPHIMURIUM; AERUGINOSA EXOENZYME S; III SECRETION SYSTEM; N-TERMINAL DOMAIN; SALMONELLA-TYPHIMURIUM; HOST-CELLS; RHO GTPASES; YERSINIA-PSEUDOTUBERCULOSIS;

D O I：

10.1016/j.chom.2009.04.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Central to the biology of many pathogenic bacteria are a number of specialized machines, known as type III, type IV, or type VI protein secretion systems. These machines have specifically evolved to deliver bacterial effector proteins into host cells with the capacity to modulate a variety of cellular functions. The identification of the biochemical activities of many effector proteins, coupled with a better understanding of their potential contribution to pathogenesis, has revealed common themes in the evolutionary design and function of these remarkable bacterial proteins.

引用

页码：571 / 579

页数：9

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