Expedient synthesis of triazole-linked glycosyl amino acids and peptides

被引：196

作者：

Kuijpers, BHM

Groothuys, S

Keereweer, AR

Quaedflieg, PJLM

Blaauw, RH

van Delft, FL

Rutjes, FPJT

机构：

[1] Univ Nijmegen, NSRIM, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands

[2] DSM Res & Patents, Life Sci Adv Synth, Catal & Dev, NL-6160 MD Geleen, Netherlands

[3] Chiralix BV, NL-6525 EC Nijmegen, Netherlands

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 18期

关键词：

D O I：

10.1021/ol048841o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expedient, high-yielding synthesis of two types of triazole-linked glycopeptides is described. These novel and stable glycopeptide mimics were prepared via Cu(I)-catalyzed [3 + 2] cycloaddition of either azide-functionalized glycosides and acetylenic amino acids or acetylenic glycosides and azide-containing amino acids.

引用

收藏

页码：3123 / 3126

页数：4

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