Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry

被引：42

作者：

Anker, Jeffrey N. ^{[1
]}

Hall, W. Paige ^{[1
]}

Lambert, Mary P. ^{[2
]}

Velasco, Pauline T. ^{[2
]}

Mrksich, Milan ^{[3
]}

Klein, William L. ^{[2
]}

Van Duyne, Richard P. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[3] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2009年 / 113卷 / 15期

关键词：

SURFACE-PLASMON RESONANCE; ALZHEIMERS-DISEASE; BETA; OLIGOMERS; NEUROTOXICITY; AGGREGATION; BIOMARKER; PEPTIDE; SENSORS; MEMORY;

D O I：

10.1021/jp900266k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.

引用

页码：5891 / 5894

页数：4

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