Life-threatening sepsis caused by Burkholderia cepacia from contaminated intravenous flush solutions prepared by a compounding pharmacy in another state

被引：27

作者：

Held, Melissa R.

Begier, Elizabeth M.

Beardsley, Diana S.

Browne, Frederick A.

Martinello, Richard A.

Baltimore, Robert S.

McDonald, L. Clifford

Jensen, Bette

Hadler, James L.

Dembry, Louise-Marie

机构：

[1] Yale Univ, Sch Med, Dept Pediat, Div Infect Dis, New Haven, CT USA

[2] Yale Univ, Sch Med, Dept Pediat, Div Hematol Oncol, New Haven, CT USA

[3] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT USA

[4] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT USA

[5] Connecticut Dept Publ Hlth, Infect Dis Div, Hartford, CT USA

[6] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA USA

[7] Ctr Dis Control & Prevent, Div Healthcare qual Promot, Atlanta, GA USA

[8] Yale New Haven Med Ctr, Dept Lab Med, New Haven, CT USA

[9] VA Connecticut Healthcare Syst, Dept Internal Med, West Haven, CT USA

[10] VA Connecticut Healthcare Syst, Clin Epidemiol Res Ctr, West Haven, CT USA

来源：

PEDIATRICS | 2006年 / 118卷 / 01期

关键词：

Burkholderia cepacia; compounding; contamination; antibiotic-lock solution; sepsis;

D O I：

10.1542/peds.2005-2617

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report 2 life-threatening cases of Burkholderia cepacia sepsis caused by infusate contamination during compounding. Bacterial isolates from the patients' blood cultures and the infusate were indistinguishable by pulsed-field gel electrophoresis. Proper quality controls at a local and national level are important for ensuring safe delivery of compounded medications to patients in all settings, including those outside health care facilities.

引用

页码：E212 / E215

页数：4

共 25 条

[1]

*AM SOC HLTH SYST, 2000, AM J HEALTH-SYST PH, V57, P150

[2]

Anonymous, 2005, Morbidity and Mortality Weekly Report, V54, P269

[3] Histopathologic features of Burkholderia cepacia pneumonia in patients without cystic fibrosis [J].