Presenilin mutants subvert chaperone function

被引：11

作者：

Gething, MJ ^{[1
]}

机构：

[1] Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic 3052, Australia

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 02期

关键词：

D O I：

10.1038/35000090

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mutant presenilin proteins, known to promote the development of Alzheimer's disease through increased generation of A beta(42) peptides, appear to compound this insult by downregulating the signalling pathway that adjusts levels of molecular chaperones in the endoplasmic reticulum in response to stress.

引用

页码：E21 / E23

页数：3

共 14 条

[1] The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Brown, MS
Goldstein, JL
[J]. CELL, 1997, 89 (03) : 331 - 340
[2] Chernoff YO, 1999, MOL CELL BIOL, V19, P8103
[3] Chaperone-supervised conversion of prion protein to its protease-resistant form
DebBurman, SK
Raymond, GJ
Caughey, B
Lindquist, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) : 13938 - 13943
[4] Role and regulation of the ER chaperone BiP
Gething, MJ
[J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1999, 10 (05) : 465 - 472
[5] Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
Haze, K
Yoshida, H
Yanagi, H
Yura, T
Mori, K
[J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (11) : 3787 - 3799
[6] Identification of a novel aspartic protease (Asp 2) as β-secretase
Hussain, I
Powell, D
Howlett, DR
Tew, DG
Week, TD
Chapman, C
Gloger, IS
Murphy, KE
Southan, CD
Ryan, DM
Smith, TS
Simmons, DL
Walsh, FS
Dingwall, C
Christie, G
[J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 1999, 14 (06) : 419 - 427
[7] Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
Katayama, T
Imaizumi, K
Sato, N
Miyoshi, K
Kudo, T
Hitomi, J
Morihara, T
Yoneda, T
Gomi, F
Mori, Y
Nakano, Y
Takeda, J
Tsuda, T
Itoyama, Y
Murayama, O
Takashima, A
St George-Hyslop, P
Takeda, M
Tohyama, M
[J]. NATURE CELL BIOLOGY, 1999, 1 (08) : 479 - 485
[8] Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
Kaufman, RJ
[J]. GENES & DEVELOPMENT, 1999, 13 (10) : 1211 - 1233
[9] A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response
Niwa, M
Sidrauski, C
Kaufman, RJ
Walter, P
[J]. CELL, 1999, 99 (07) : 691 - 702
[10] The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
Selkoe, DJ
[J]. TRENDS IN CELL BIOLOGY, 1998, 8 (11) : 447 - 453

← 1 2 →