Aging in rhesus monkeys: Relevance to human health interventions

被引:252
作者
Roth, GS
Mattison, JA
Ottinger, MA
Chachich, ME
Lane, MA
Ingram, DK
机构
[1] NIA, Lab Expt Gerontol, Intramural Res Program, Gerontol Res Ctr,NIH, Baltimore, MD 21224 USA
[2] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA
关键词
D O I
10.1126/science.1102541
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Progress in gerontologicat research has been promoted through the use of numerous animal models, which have helped identify possible mechanisms of aging and age-related chronic diseases and evaluate possible interventions with potential relevance to human aging and disease. Further development of nonhuman primate models, particularly rhesus monkeys, could accelerate this progress, because their closer genetic relationship to humans produces a highly similar aging phenotype. Because the relatively tong lives of primates increase the administrative and economic demands on research involving them, new emphasis has emerged on increasing the efficient use of these valuable resources through cooperative, interdisciplinary research.
引用
收藏
页码:1423 / 1426
页数:4
相关论文
共 62 条
[1]   PATHOLOGICAL-CHANGES IN THE REPRODUCTIVE-TRACT OF MALE RHESUS-MONKEYS ASSOCIATED WITH AGE AND SIMIAN AIDS [J].
BASKERVILLE, A ;
COOK, RW ;
DENNIS, MJ ;
CRANAGE, MP ;
GREENAWAY, PJ .
JOURNAL OF COMPARATIVE PATHOLOGY, 1992, 107 (01) :49-57
[2]   Nonhuman Primate Models of Menopause Workshop [J].
Bellino, FL ;
Wise, PM .
BIOLOGY OF REPRODUCTION, 2003, 68 (01) :10-18
[3]   A nonhuman primate model of age-related bone loss: A longitudinal study in male and premenopausal female rhesus monkeys [J].
Black, A ;
Tilmont, EM ;
Handy, AM ;
Scott, WW ;
Shapses, SA ;
Ingram, DK ;
Roth, GS ;
Lane, MA .
BONE, 2001, 28 (03) :295-302
[4]   The effects of K-111, a new insulin-sensitizer, on metabolic syndrome in obese prediabetic rhesus monkeys [J].
Bodkin, NL ;
Pill, J ;
Meyer, K ;
Hansen, BC .
HORMONE AND METABOLIC RESEARCH, 2003, 35 (10) :617-624
[5]  
Bodkin NL, 2003, J GERONTOL A-BIOL, V58, P212
[6]   LONG-TERM DIETARY RESTRICTION IN OLDER-AGED RHESUS-MONKEYS - EFFECTS ON INSULIN-RESISTANCE [J].
BODKIN, NL ;
ORTMEYER, HK ;
HANSEN, BC .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1995, 50 (03) :B142-B147
[7]  
Brewer M, 2001, COMPARATIVE MED, V51, P424
[8]   Reduction in hippocampal cholinergic innervation is unrelated to recognition memory impairment in aged rhesus monkeys [J].
Calhoun, ME ;
Mao, Y ;
Roberts, JA ;
Rapp, PR .
JOURNAL OF COMPARATIVE NEUROLOGY, 2004, 475 (02) :238-246
[9]  
CHAKRABORTY M, 1995, CANCER RES, V55, P1525
[10]  
CLARKSON TB, 1994, JAMA-J AM MED ASSOC, V271, P317