Aging in rhesus monkeys: Relevance to human health interventions

被引:252
作者
Roth, GS
Mattison, JA
Ottinger, MA
Chachich, ME
Lane, MA
Ingram, DK
机构
[1] NIA, Lab Expt Gerontol, Intramural Res Program, Gerontol Res Ctr,NIH, Baltimore, MD 21224 USA
[2] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA
关键词
D O I
10.1126/science.1102541
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Progress in gerontologicat research has been promoted through the use of numerous animal models, which have helped identify possible mechanisms of aging and age-related chronic diseases and evaluate possible interventions with potential relevance to human aging and disease. Further development of nonhuman primate models, particularly rhesus monkeys, could accelerate this progress, because their closer genetic relationship to humans produces a highly similar aging phenotype. Because the relatively tong lives of primates increase the administrative and economic demands on research involving them, new emphasis has emerged on increasing the efficient use of these valuable resources through cooperative, interdisciplinary research.
引用
收藏
页码:1423 / 1426
页数:4
相关论文
共 62 条
[51]   Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta).: J Med Primatol 30:161-173 2001 [J].
Smucny, DA ;
Allison, DB ;
Ingram, DK ;
Roth, GS ;
Kemnitz, JW ;
Kohama, SG ;
Lane, MA ;
Black, A .
JOURNAL OF MEDICAL PRIMATOLOGY, 2004, 33 (01) :48-54
[52]   The metabolic syndrome: An emerging health epidemic in women [J].
Steinbaum, SR .
PROGRESS IN CARDIOVASCULAR DISEASES, 2004, 46 (04) :321-336
[53]   Age-related changes in auditory function of rhesus monkeys (Macaca mulatta) [J].
Torre, P ;
Fowler, CG .
HEARING RESEARCH, 2000, 142 (1-2) :131-140
[54]   Cerebral amyloid angiopathy and plaques, and visceral amyloidosis in aged macaques [J].
Uno, H ;
Alsum, PB ;
Dong, S ;
Richardson, R ;
Zimbric, ML ;
Thieme, CS ;
Houser, WD .
NEUROBIOLOGY OF AGING, 1996, 17 (02) :275-281
[55]  
Valverde CR, 2000, COMPARATIVE MED, V50, P540
[56]  
Voytko ML, 2001, SYNAPSE, V39, P95, DOI 10.1002/1098-2396(20010101)39:1<95::AID-SYN12>3.0.CO
[57]  
2-2
[58]   Impairments in acquisition and reversals of two-choice discriminations by aged rhesus monkeys [J].
Voytko, ML .
NEUROBIOLOGY OF AGING, 1999, 20 (06) :617-627
[59]  
Weindruch R., 1988, RETARDATION AGING DI
[60]  
Winegar DA, 2001, J LIPID RES, V42, P1543