Tyrosine dephosphorylation underlies DHPG-induced LTD

被引：45

作者：

Moult, PR

Schnabel, R

Kilpatrick, IC

Bashir, ZI

Collingridge, GL

机构：

[1] Univ Bristol, Dept Anat, MRC, Ctr Synapt Plastic, Bristol BS8 1TD, Avon, England

[2] Knoll Pharmaceut, Res & Dev, Nottingham NG1 1GF, England

来源：

NEUROPHARMACOLOGY | 2002年 / 43卷 / 02期

基金：

英国医学研究理事会;

关键词：

LTD; DHPG; mGlu; tyrosine; PTK; PTP; glutamate receptor; synaptic plasticity;

D O I：

10.1016/S0028-3908(02)00110-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A form of long-term depression (LTD) of synaptic transmission can be induced by bath application of the group I metabotropic glutamate (mGlu) receptor agonist (RS)-3,5-dihydroxyphenylglycine (DHPG). The mechanisms responsible for the induction and expression of DHPG-induced LTD in the CA1 region of the hippocampus are currently the subject of intense investigation. Here we show that two protein tyrosine kinase (PTK) inhibitors (10 muM lavendustin A or 30 muM genistein) have little effect on DHPG-induced LTD. In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 muM phenyl-arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：175 / 180

页数：6

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