Antigenic variation in Trypanosoma brucei:: facts, challenges and mysteries

被引：112

作者：

Pays, E ^{[1
]}

Vanhamme, L ^{[1
]}

Pérez-Morga, D ^{[1
]}

机构：

[1] Free Univ Brussels, Mol Parasitol Lab, IBMM, B-6041 Gosselies, Belgium

来源：

CURRENT OPINION IN MICROBIOLOGY | 2004年 / 7卷 / 04期

关键词：

D O I：

10.1016/j.mib.2004.05.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antigenic variation allows African trypanosomes to develop chronic infections in mammalian hosts. This process results from the alternative occurrence of transcriptional switching and DNA recombination targeted to a telomeric locus that contains the gene of the variant antigen and is subjected to mono-allelic expression control. So far, the identification of mechanisms and factors involved still resists technological developments and genome sequencing.

引用

页码：369 / 374

页数：6

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