Identification of a metabolite of atrazine, N-ethyl-6-methoxy-N′-(1-methylethyl)-1,3,5-triazine-2,4-diamine, upon incubation with rat liver microsomes

被引：13

作者：

Li, Aiqun ^{[1
]}

May, Matthew P. ^{[1
]}

Bigelow, James C. ^{[1
]}

机构：

[1] Idaho State Univ, Coll Pharm, Dept Pharmaceut Sci, Pocatello, ID 83209 USA

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2006年 / 836卷 / 1-2期

关键词：

atrazine; atraton; LC/MS/MS; metabolite;

D O I：

10.1016/j.jchromb.2006.03.041

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Atrazine is an herbicide which has shown potential antimalarial effects both in vitro and in vivo in rats. In order to study the metabolism of atrazine in rat livers. we developed a sensitive LC/MS/MS method for the identification of atrazine and several of its metabolites. Using this method, we identified one previously unreported metabolite with a mass of 211 Da in addition to two known metabolites. This new metabolite was confirmed to be N-ethyl-6-methoxv-N'-(1-methylethyl)-1,3,5-triazine-2,4-diamine, also known as atraton, by comparison of the LC/MS/MS mass spectra and the retention time to those of a commercial standard. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：129 / 132

页数：4

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