Ectopic discharge in Aβ afferents as a source of neuropathic pain

被引：318

作者：

Devor, Marshall ^{[1
,2
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Cell & Dev Biol, Inst Life Sci, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Ctr Res Pain, IL-91904 Jerusalem, Israel

来源：

EXPERIMENTAL BRAIN RESEARCH | 2009年 / 196卷 / 01期

关键词：

A beta pain; Neuropathic pain; Phenotypic switch; Tactile allodynia; DORSAL-ROOT GANGLION; CHRONIC CONSTRICTION INJURY; PERIPHERAL-NERVE INJURY; MEMBRANE-POTENTIAL OSCILLATIONS; INDUCED TACTILE ALLODYNIA; PHANTOM-LIMB PAIN; SODIUM-CHANNELS; SUBSTANCE-P; CENTRAL SENSITIZATION; MYELINATED AFFERENTS;

D O I：

10.1007/s00221-009-1724-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ectopic discharge in axotomized dorsal root ganglion neurons is a key driver of neuropathic pain. However, the bulk of this activity is generated and carried centrally in large diameter myelinated A beta afferents, a cell type that normally signals touch and vibration sense. Evidence is considered suggesting that following axotomy, A beta afferents undergo a change in their electrical characteristics and also in the neurotransmitter complement that they express. This dual phenotypic switching renders them capable of (1) directly driving postsynaptic pain signaling pathways in the spinal cord, and (2) triggering and maintaining central sensitization.

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页码：115 / 128

页数：14

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