RETRACTED: A new MHC locus that influences class I peptide presentation (Retracted article. See vol 11, pg U9, 1999)

被引:14
作者
Simmons, WA
Roopenian, DC
Summerfield, SG
Jones, RC
Galocha, B
Christianson, GJ
Maika, SD
Zhou, M
Gaskell, SJ
Bordoli, RS
Ploegh, HL
Slaughter, CA
Lindahl, KF
Hammer, RE
Taurog, JD
机构
[1] UNIV TEXAS, SW MED CTR, HAROLD C SIMMONS ARTHRIT RES CTR, DEPT INTERNAL MED, DALLAS, TX 75235 USA
[2] UNIV TEXAS, SW MED CTR, HOWARD HUGHES MED INST, DEPT BIOCHEM, DALLAS, TX 75235 USA
[3] UNIV TEXAS, SW MED CTR, DEPT MICROBIOL, DALLAS, TX 75235 USA
[4] JACKSON LAB, BAR HARBOR, ME 04609 USA
[5] UMIST, DEPT CHEM, MANCHESTER M60 1QD, LANCS, ENGLAND
[6] MIT, CTR CANC RES, CAMBRIDGE, MA 02139 USA
[7] MICROMASS UK LTD, MANCHESTER M23 9LE, LANCS, ENGLAND
关键词
D O I
10.1016/S1074-7613(00)80385-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have investigated the HLA-B27-restricted CTL response to HY minor histocompatibility antigens in rats and mice transgenic for HLA-B27 and human beta 2-microglobulin. A polymorphism was found at a locus within the H2 complex, producing two distinct but overlapping sets of B27-presented HY peptides. The locus, named Cim2, mapped between the K and Pb loci, and its product is therefore distinct from TAP, LMP, and tapasin. Identical findings in rats and mice, including identical HY peptide sequences and the failure of a rat Tap2A transgene to alter CTL recognition, suggest that a homologous locus with similar polymorphism exists in the rat. Cim2, or a closely linked locus, was found to exert a broad effect on peptide loading of both HLA-B27 and mouse class I alleles. The data thus establish a strong, previously unrecognized MHC-encoded influence on the class I antigen pathway.
引用
收藏
页码:641 / 651
页数:11
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