Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol

被引：14

作者：

Vasdev, Neil ^{[1
,2
]}

Chio, Jason ^{[3
]}

van Oosten, Erik M. ^{[1
,3
]}

Nitz, Mark ^{[3
]}

McLaurin, JoAnne ^{[4
]}

Vines, Douglass C. ^{[5
,6
]}

Houle, Sylvain ^{[1
,2
]}

Reilly, Raymond M. ^{[7
]}

Wilson, Alan A. ^{[1
,2
]}

机构：

[1] Ctr Addict & Mental Hlth, PET Ctr, Toronto, ON M5T 1R8, Canada

[2] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada

[3] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada

[4] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON M5S 3H2, Canada

[5] Princess Margaret Hosp, Radiat Med Program, STTARR Innovat Ctr, Toronto, ON M5G 1L7, Canada

[6] Univ Toronto, Dept Radiat Oncol, Toronto, ON M5S 3E2, Canada

[7] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON M5S 3M2, Canada

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 37期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; BETA AGGREGATION; SCYLLO-INOSITOL;

D O I：

10.1039/b913317h

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel PET radiotracer, [F-18]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.

引用

页码：5527 / 5529

页数：3

共 18 条

[1]

Molecular imaging with PET [J].

Ametamey, Simon M. ;

Honer, Michael ;

Schubiger, Pius August .

CHEMICAL REVIEWS, 2008, 108 (05) :1501-1516

[2]

Dissecting Molecular Mechanisms in the Living Brain of Dementia Patients [J].

Barrio, Jorge R. ;

Satyamurthy, Nagichettiar ;

Huang, Sung-Cheng ;

Petric, Andrej ;

Small, Gary W. ;

Kepe, Vladimir .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (07) :842-850

[3]

Chemistry with [18F]fluoride ion [J].

Cai, Lisheng ;

Lu, Shuiyu ;

Pike, Victor W. .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2008, 2008 (17) :2853-2873

[4]

Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology [J].

Fenili, Daniela ;

Brown, Mary ;

Rappaport, Rebecca ;

McLaurin, JoAnne .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2007, 85 (06) :603-611

[5]

H-1-NMR SPECTROSCOPIC CHARACTERIZATION OF PERCHLORIC-ACID EXTRACTS FROM BREAST CARCINOMAS AND NONINVOLVED BREAST-TISSUE [J].

GRIBBESTAD, IS ;

PETERSEN, SB ;

FJOSNE, HE ;

KVINNSLAND, S ;

KRANE, J .

NMR IN BIOMEDICINE, 1994, 7 (04) :181-194

[6]

The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation [J].

Klunk, William E. ;

Mathis, Chester A. .

CURRENT OPINION IN NEUROLOGY, 2008, 21 (06) :683-687

[7]

Molecular imaging as a tool for personalized and targeted anticancer therapy [J].

McLarty, K. ;

Reilly, R. M. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2007, 81 (03) :420-424

[8]

MCLARTY K, J NUCL MED UNPUB

[9]

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model [J].

McLaurin, JoAnne ;

Kierstead, Meredith E. ;

Brown, Mary E. ;

Hawkes, Cheryl A. ;

Lambermon, Mark H. L. ;

Phinney, Amie L. ;

Darabie, Audrey A. ;

Cousins, Julian E. ;

French, Janet E. ;

Lan, Melissa F. ;

Chen, Fusheng ;

Wong, Sydney S. N. ;

Mount, Howard T. J. ;

Fraser, Paul E. ;

Westaway, David ;

St George-Hyslop, Peter .

NATURE MEDICINE, 2006, 12 (07) :801-808

[10]

Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography [J].

Miller, Philip W. ;

Long, Nicholas J. ;

Vilar, Ramon ;

Gee, Antony D. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (47) :8998-9033

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