Intracellular delivery of quantum dots for live cell labeling and organelle tracking

被引:460
作者
Derfus, AM [1 ]
Chan, WCW [1 ]
Bhatia, SN [1 ]
机构
[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
关键词
D O I
10.1002/adma.200306111
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Several strategies borrowed from the field of gene delivery are adapted to enhance delivery of semiconductor quantum dots (QDs) to the interior of live cells. To traffic QDs to subcellular organelles, QDs were then derivatized with known peptide localization sequences, demonstrating the ability to target QDs to the nucleus and mitochondria (see Figure).
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页码:961 / +
页数:7
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