Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans

被引：40

作者：

Chabane, N

Millet, B

Delorme, R

Lichtermann, D

Mathieu, F

Laplanche, JL

Roy, I

Mouren, MC

Hankard, R

Maier, W

Launay, JM

Leboyer, M

机构：

[1] Hop Robert Debre, Serv Psychopathol Enfant & Adolescent, Assistance Publ Hop Paris, F-75019 Paris, France

[2] Hop Robert Debre, Ctr Invest Clin, Assistance Publ Hop Paris, F-75019 Paris, France

[3] Hop Henri Mondor & Albert Chenevier, Psychiat Serv, Assistance Publ Hop Paris, F-94010 Creteil, France

[4] Hop Lariboisiere, Assistance Publ Hop Paris, Cent Biochim Lab, F-75475 Paris, France

[5] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany

[6] Univ Paris, INSERM E0 117, Dept Psychiat, St Anne Hosp, F-75674 Paris, France

[7] Hop Henri Mondor, Lab Neurobiol & Psychiat, INSERM U513, F-94010 Creteil, France

来源：

NEUROSCIENCE LETTERS | 2004年 / 363卷 / 02期

关键词：

serotonin transporter gene; obsessive-compulsive disorder; case control; family study;

D O I：

10.1016/j.neulet.2004.03.065

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Association studies of the serotonin transporter (SLC6A4) gene in obsessive-compulsive disorder (OCD) have generated discrepant results. Here, we genotyped the 5-HTTLPR polymorphism in 106 French OCD patients and 171 healthy controls (case control study). We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：154 / 156

页数：3

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