Neutrophil transepithelial migration and epithelial barrier function in IBD - Potential targets for inhibiting neutrophil trafficking

被引：93

作者：

Chin, Alex C. ^{[1
]}

Parkos, Charles A. ^{[1
]}

机构：

[1] Emory Univ, Dept Pathol & Lab Med, Epithelial Pathobiol Unit, Atlanta, GA 30322 USA

来源：

INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS | 2006年 / 1072卷

关键词：

meutrophil; transmigration; epithelium; apical junction complex; permeability; IBD;

D O I：

10.1196/annals.1326.018

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Neutrophil (PMN) transmigration across mucosal epithelia is a hallmark of inflammatory conditions, such as ulcerative colitis and Crohn's disease. PMN accumulation within epithelial crypts and in the intestinal lumen directly correlates with clinical disease activity and epithelial injury. Currently, the mechanisms by which PMNs migrate across mucosal epithelia are incompletely understood and a better understanding of this process will likely provide new insights into novel treatment strategies for inflammatory bowel disease. In this article, we discuss current advances that define PMN transepithelial migration, specifically focusing on PMN-epithelial adhesive interactions and signaling events. We also describe how these interactions might be specifically targeted for the development of therapeutic strategies to manage mucosal inflammation.

引用

页码：276 / 287

页数：12

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