Cellular immune reactions directed against Toxoplasma gondii with special emphasis on the central nervous system

被引:24
作者
Daubener, W
Hadding, U
机构
[1] Institut für Med., Mikrobiologie und Virologie, Heinrich-Heine-Universität, D-40001 Düsseldorf, Düsseldorf
关键词
Toxoplasma; indolamine 2,3-dioxygenase; nitric oxide; T cell; central nervous system; encephalitis;
D O I
10.1007/s004300050031
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Toxoplasma gondii is an obligate intracellular parasite which, after primary infection of humans, is maintained in a dormant state by the host cellular immune system. In the event of an acquired immunosuppression, those parasites surviving as dormant cysts in the host may undergo a change in status, proliferate and cause a life-threatening toxoplasmic encephalitis. Over the last decade much knowlege has accumulated concerning the immune response against T. gondii. This review focuses attention particularly on the anti-parasitic effector mechanisms and the cellular immune reactions in the central nervous system during the course of reactivated toxoplasmic encephalitis.
引用
收藏
页码:195 / 206
页数:12
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