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Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer

被引：389
作者：
Nishita, M
Hashimoto, MK
Ogata, S
Laurent, MN
Ueno, N
Shibuya, H [1 ]
Cho, KWY
机构：
[1] Natl Inst Basic Biol, Dept Dev Biol, Div Morphogenesis, Okazaki, Aichi 4448585, Japan
[2] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92617 USA
来源：
NATURE | 2000年 / 403卷 / 6771期
关键词：
D O I：
10.1038/35001602
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Members of the Wnt and TGF-beta superfamilies regulate both cell fate and proliferation during development and tissue maintenance(1-3). In the early amphibian embryo, the Wnt and TGF-beta superfamily signalling cascades are required for the establishment of a dorsal signalling centre, Spemann's organizer(4-8). Intracellular proteins of both pathways, upon activation, translocate to the nucleus to participate in transcription. Here we show that beta-catenin and Lef1/Tcf, which are downstream components of the Wnt signalling cascade, form a complex with Smad4, an essential mediator of signals initiated by members of the TGF-beta growth factor superfamily. In Xenopus, this interaction directly and synergistically affects expression of the twin (Xtwn) gene during formation of the organizer. This is, to our knowledge, the first demonstration of a physical interaction between TGF-beta and Wnt signalling components in vivo.
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页码：781 / 785
页数：5
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