THE CANDIDATE PROTOONCOGENE BCL-3 ENCODES A TRANSCRIPTIONAL COACTIVATOR THAT ACTIVATES THROUGH NF-KAPPA-B P50 HOMODIMERS

被引：351

作者：

FUJITA, T ^{[1
]}

NOLAN, GP ^{[1
]}

LIOU, HC ^{[1
]}

SCOTT, ML ^{[1
]}

BALTIMORE, D ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEW YORK,NY 10021

来源：

GENES & DEVELOPMENT | 1993年 / 7卷 / 7B期

关键词：

NF-KAPPA-B; P50; I-KAPPA-B; TRANSCRIPTION; COACTIVATOR;

D O I：

10.1101/gad.7.7b.1354

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with IkappaB-alpha and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of IkappaB-alpha, the bcl-3 gene product superactivates NF-kappaB p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a kappaB motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.

引用

页码：1354 / 1363

页数：10

共 45 条

[1] ACTIVATION OF DNA-BINDING ACTIVITY IN AN APPARENTLY CYTOPLASMIC PRECURSOR OF THE NF-KAPPA-B TRANSCRIPTION FACTOR
BAEUERLE, PA
BALTIMORE, D
[J]. CELL, 1988, 53 (02) : 211 - 217
[2] A 65-KD SUBUNIT OF ACTIVE NF-KAPPA-B IS REQUIRED FOR INHIBITION OF NF-KAPPA-B BY I-KAPPA-B
BAEUERLE, PA
BALTIMORE, D
[J]. GENES & DEVELOPMENT, 1989, 3 (11) : 1689 - 1698
[3] I-KAPPA-B - A SPECIFIC INHIBITOR OF THE NF-KAPPA-B TRANSCRIPTION FACTOR
BAEUERLE, PA
BALTIMORE, D
[J]. SCIENCE, 1988, 242 (4878) : 540 - 546
[4] BINDING OF A NUCLEAR FACTOR TO A REGULATORY SEQUENCE IN THE PROMOTER OF THE MOUSE H-2KB CLASS-I MAJOR HISTOCOMPATIBILITY GENE
BALDWIN, AS
SHARP, PA
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (01) : 305 - 313
[5] I-KAPPA-B INTERACTS WITH THE NUCLEAR-LOCALIZATION SEQUENCES OF THE SUBUNITS OF NF-KAPPA-B - A MECHANISM FOR CYTOPLASMIC RETENTION
BEG, AA
RUBEN, SM
SCHEINMAN, RI
HASKILL, S
ROSEN, CA
BALDWIN, AS
[J]. GENES & DEVELOPMENT, 1992, 6 (10) : 1899 - 1913
[6] CYTOPLASMIC RETENTION, DNA-BINDING AND PROCESSING OF THE NF-KAPPA-B P50 PRECURSOR ARE CONTROLLED BY A SMALL REGION IN ITS C-TERMINUS
BLANK, V
KOURILSKY, P
ISRAEL, A
[J]. EMBO JOURNAL, 1991, 10 (13) : 4159 - 4167
[7] THE ONCOPROTEIN BCL-3 DIRECTLY TRANSACTIVATES THROUGH KAPPA-B MOTIFS VIA ASSOCIATION WITH DNA-BINDING P50B HOMODIMERS
BOURS, V
FRANZOSO, G
AZARENKO, V
PARK, S
KANNO, T
BROWN, K
SIEBENLIST, U
[J]. CELL, 1993, 72 (05) : 729 - 739
[8] A NOVEL MITOGEN-INDUCIBLE GENE-PRODUCT RELATED TO P50/P105-NF-KAPPA-B PARTICIPATES IN TRANSACTIVATION THROUGH A KAPPA-B SITE
BOURS, V
BURD, PR
BROWN, K
VILLALOBOS, J
PARK, S
RYSECK, RP
BRAVO, R
KELLY, K
SIEBENLIST, U
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (02) : 685 - 695
[9] DEVELOPMENTAL AND TISSUE-SPECIFIC EXPRESSION OF NUCLEAR PROTEINS THAT BIND THE REGULATORY ELEMENT OF THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENE
BURKE, PA
HIRSCHFELD, S
SHIRAYOSHI, Y
KASIK, JW
HAMADA, K
APPELLA, E
OZATO, K
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (04) : 1309 - 1321
[10] REGULATED EXPRESSION OF 3 C/EBP ISOFORMS DURING ADIPOSE CONVERSION OF 3T3-L1 CELLS
CAO, ZD
UMEK, RM
MCKNIGHT, SL
[J]. GENES & DEVELOPMENT, 1991, 5 (09) : 1538 - 1552

← 1 2 3 4 5 →