THE CANDIDATE PROTOONCOGENE BCL-3 ENCODES A TRANSCRIPTIONAL COACTIVATOR THAT ACTIVATES THROUGH NF-KAPPA-B P50 HOMODIMERS

被引：351

作者：

FUJITA, T ^{[1
]}

NOLAN, GP ^{[1
]}

LIOU, HC ^{[1
]}

SCOTT, ML ^{[1
]}

BALTIMORE, D ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEW YORK,NY 10021

来源：

GENES & DEVELOPMENT | 1993年 / 7卷 / 7B期

关键词：

NF-KAPPA-B; P50; I-KAPPA-B; TRANSCRIPTION; COACTIVATOR;

D O I：

10.1101/gad.7.7b.1354

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with IkappaB-alpha and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of IkappaB-alpha, the bcl-3 gene product superactivates NF-kappaB p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a kappaB motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.

引用

页码：1354 / 1363

页数：10

共 45 条

[31] THE NF-KAPPA-B PRECURSOR P105 AND THE PROTOONCOGENE PRODUCT BCL-3 ARE I-KAPPA-B MOLECULES AND CONTROL NUCLEAR TRANSLOCATION OF NF-KAPPA-B
NAUMANN, M
WULCZYN, FG
SCHEIDEREIT, C
[J]. EMBO JOURNAL, 1993, 12 (01) : 213 - 222
[32] B-CELL LYMPHOMA-ASSOCIATED CHROMOSOMAL TRANSLOCATION INVOLVES CANDIDATE ONCOGENE LYT-10, HOMOLOGOUS TO NF-KAPPA-B P50
NERI, A
CHANG, CC
LOMBARDI, L
SALINA, M
CORRADINI, P
MAIOLO, AT
CHAGANTI, RSK
DALLAFAVERA, R
[J]. CELL, 1991, 67 (06) : 1075 - 1087
[33] The inhibitory ankyrin and activator Rel proteins
Nolan, Garry P.
Baltimore, David
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1992, 2 (02) : 211 - 220
[34] THE BCL-3 PROTOONCOGENE ENCODES A NUCLEAR I-KAPPA-B-LIKE MOLECULE THAT PREFERENTIALLY INTERACTS WITH NF-KAPPA-B P50 AND P52 IN A PHOSPHORYLATION-DEPENDENT MANNER
NOLAN, GP
FUJITA, T
BHATIA, K
HUPPI, C
LIOU, HC
SCOTT, ML
BALTIMORE, D
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (06) : 3557 - 3566
[35] DNA-BINDING AND I-KAPPA-B INHIBITION OF THE CLONED P65 SUBUNIT OF NF-KAPPA-B, A REL-RELATED POLYPEPTIDE
NOLAN, GP
GHOSH, S
LIOU, HC
TEMPST, P
BALTIMORE, D
[J]. CELL, 1991, 64 (05) : 961 - 969
[36] THE CANDIDATE PROTOONCOGENE BCL-3 IS RELATED TO GENES IMPLICATED IN CELL LINEAGE DETERMINATION AND CELL-CYCLE CONTROL
OHNO, H
TAKIMOTO, G
MCKEITHAN, TW
[J]. CELL, 1990, 60 (06) : 991 - 997
[37] SCHMID RM, 1991, NATURE, V352, P734
[38] THE P65 SUBUNIT IS RESPONSIBLE FOR THE STRONG TRANSCRIPTION ACTIVATING POTENTIAL OF NF-KAPPA-B
SCHMITZ, ML
BAEUERLE, PA
[J]. EMBO JOURNAL, 1991, 10 (12) : 3805 - 3817
[39] SCOTT ML, 1993, IN PRESS GENES DEV
[40] AN LFA-3 CDNA ENCODES A PHOSPHOLIPID-LINKED MEMBRANE-PROTEIN HOMOLOGOUS TO ITS RECEPTOR CD2
SEED, B
[J]. NATURE, 1987, 329 (6142) : 840 - 842

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