Distachyasin:: A new antioxidant metabolite from the leaves of Carex distachya

被引：20

作者：

Fiorentino, Antonio ^{[1
]}

D'Abrosca, Brigida

Pacifico, Severina

Iacovino, Rosa

Mastellone, Claudio

Di Blasio, Benedetto

Monacoa, Pietro

机构：

[1] Seconda Univ Napoli, Dipartimento Sci Vita, I-81100 Caserta, Italy

[2] Seconda Univ Napoli, Dipartimento Sci Ambientali, I-81100 Caserta, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 23期

关键词：

distachyasin; prenyl stilbenoid; Carex distachya; spectroscopic analysis; crystallographic data; antioxidant activities;

D O I：

10.1016/j.bmcl.2006.08.106

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A novel antioxidant prenylated stilbenoid, distachyasin, has been isolated from the leaves of Carex distachya. Its structure has been elucidated on the basis of the spectroscopic characteristics. Bidimensional NMR, and crystallographic data and computational calculations have furnished important data useful for the characterization and the stereochemistry of the molecule. The compound has a tetracyclic skeleton derived from carexane. The compound has been assayed, for the antioxidant activity, by measuring its capacity to scavenge the H2O2, nitric oxide, superoxide radical and to inhibit formation of TBARS (thiobarbituric acid reactive species). (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6096 / 6101

页数：6

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