Paracrine and endocrine roles of insulin-like factor 3

被引：34

作者：

Ferlin, A. ^{[1
]}

Arredi, B. ^{[1
]}

Zuccarello, D. ^{[1
]}

Garolla, A. ^{[1
]}

Selice, R. ^{[1
]}

Foresta, C. ^{[1
]}

机构：

[1] Univ Padua, Dept Histol Microbiol & Med Biotechnol, Ctr Male Gamete Cryopreservat, I-35121 Padua, Italy

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2006年 / 29卷 / 07期

关键词：

cryptorchidism; INSL3; Leydig; LGR8; spermatogenesis;

D O I：

10.1007/BF03344168

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-like factor 3 (INSL3) is expressed in Leydig cells of the testis and theca cells of the ovary. This peptide affects testicular descent by acting on gubernaculum via its specific receptor leucine-rich repeat-containing G protein-coupled receptor 8 (LGR8). From initial animal data showing the cryptorchid phenotype of Insl3/ Lgr8 mutants, an extensive search for mutations in INSL3 and LGR8 genes was undertaken in human patients with cryptorchidism, and a frequency of mutation of 4-5% has been detected. However, definitive proofs of a causative role for some of these mutations are still lacking. More recent data suggest additional paracrine (in the testis and ovary) and endocrine actions of INSL3 in adults. INSL3 circulates at high concentrations in serum of adult males and its production is dependent on the differentiation effect of LH. Therefore, INSL3 is increasingly used as a specific marker of Leydig cell differentiation and function.

引用

页码：657 / 664

页数：8

共 47 条

[11] Hormonal control of gubernaculum development during testis descent:: Gubernaculum outgrowth in vitro requires both insulin-like factor and androgen [J].