Low-Density Lipoprotein Oxidizability and the Alteration of Its Fatty Acid Content in Renal Transplant Recipients Treated With Cyclosporine/Tacrolimus

被引：6

作者：

Bakar, F. ^{[1
]}

Keven, K. ^{[1
]}

Dogru, B. ^{[1
]}

Aktan, F. ^{[1
]}

Erturk, S. ^{[1
]}

Tuzuner, A. ^{[1
]}

Erbay, B. ^{[1
]}

Nebioglu, S. ^{[1
]}

机构：

[1] Ankara Univ, Dept Pharm, TR-06100 Ankara, Turkey

来源：

TRANSPLANTATION PROCEEDINGS | 2009年 / 41卷 / 05期

关键词：

OXIDATIVE MODIFICATION; OLEIC-ACID; SUSCEPTIBILITY; IMMUNOSUPPRESSION; PEROXIDATION; TACROLIMUS; INCREASE; RICH; LDL;

D O I：

10.1016/j.transproceed.2009.01.091

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Renal transplantation is widely used to treat patients with end-stage renal disease. Atherosclerosis is an important posttransplantation risk factor for renal transplant recipients. Subsequent to transplantation low-density lipoprotein (LDL) particles become susceptible to oxidative modification, which results in atherosclerosis. Therefore, the aim of our study was to investigate differences in the susceptibility of LDL particles to oxidation by analyzing LDL fatty acid levels among renal transplant recipients. The changes in lag phases and fatty acid levels of LDL were observed over 4 months among renal transplant recipients treated with Cyclosporine (CsA; n = 7) or Tacrolimus (FK-506; n = 9). We also analyzed cholesterol and triglyceride levels of patients and healthy controls. The lag phase at the 60th day after transplantation was significantly shorter than the results either before transplantation or among control subjects. In conclusion, a similar decrease in lag phase was observed in both above groups, but the FK-506-treated group showed a better lipid profile than the CsA-treated group.

引用

页码：1630 / 1633

页数：4

共 25 条

[1] OXIDATION OF LOW-DENSITY LIPOPROTEINS - INTRAINDIVIDUAL VARIABILITY AND THE EFFECT OF DIETARY LINOLEATE SUPPLEMENTATION [J].