Chromatin modulation and the DNA damage response

被引：30

作者：

Costelloe, Thomas

FitzGerald, Jennifer

Murphy, Niall J.

Flaus, Andrew

Lowndes, Noel F. ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Galway, Dept Biochem, Genome Stabil Lab, Galway, Ireland

[2] Natl Univ Ireland Univ Coll Galway, Natl Ctr Biomed Engn Sci, Galway, Ireland

[3] Natl Univ Ireland Univ Coll Galway, Nucleosome Dynam Lab, Dept Biochem, Galway, Ireland

来源：

EXPERIMENTAL CELL RESEARCH | 2006年 / 312卷 / 14期

关键词：

DNA; chromatin; DNA damage response; histone;

D O I：

10.1016/j.yexcr.2006.06.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：2677 / 2686

页数：10

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