Secondary structure, dynamics, and topology of a seven-helix receptor in native membranes, studied by solid-state NMR spectroscopy

被引：155

作者：

Etzkorn, Manuel

Martell, Swetlana

Andronesi, Ovidiu C.

Seidel, Karsten

Engelhard, Martin

Baldus, Marc

机构：

[1] Max Planck Inst Mol Physiol, Phys Biochem Abt, D-44227 Dortmund, Germany

[2] Max Planck Inst Biophys Chem, Abt NMR Basierte Strukt Biol, D-37077 Gottingen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 03期

关键词：

membrane proteins; molecular dynamics; NMR spectroscopy; receptors; structure elucidation;

D O I：

10.1002/anie.200602139

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the loop: High-resolution solid-state NMR spectroscopy is used to study the secondary structure, dynamics, and membrane topology of an entire seven-helix receptor, sensory rhodopsin II from Natronomonas pharaonis (see picture). The experiments are carried out on a single isotope-labeled sample in a native membrane environment. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：459 / 462

页数：4

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