Integrins, adhesion and apoptosis

被引：238

作者：

Meredith, JE

Schwartz, MA

机构：

[1] Dept. of Vascular Biology, Scripps Research Institute, La Jolla, CA 92037

来源：

TRENDS IN CELL BIOLOGY | 1997年 / 7卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(97)01002-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrin-mediated adhesion to extracellular matrix proteins is required for survival of many cell types. This phenomenon appears to be a mechanism of tumour suppression and to participate in embryogenesis. Here, our current understanding of how integrin-dependent signals prevent apoptosis and implications of anchorage-dependent survival for development physiology and pathology are discussed.

引用

收藏

页码：146 / 150

页数：5

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