Relationship of dehydroepiandrosterone and cortisol in disease

被引:78
作者
Hechter, O
Grossman, A
Chatterton, RT
机构
[1] NORTHWESTERN UNIV, SCH MED, DEPT MOL & CELL BIOL, CHICAGO, IL 60615 USA
[2] NORTHWESTERN UNIV, SCH MED, DEPT OBSTET & GYNECOL, CHICAGO, IL 60615 USA
[3] RUSH PRESBYTERIAN ST LUKES MED CTR, DEPT PEDIAT, CHICAGO, IL 60612 USA
关键词
D O I
10.1016/S0306-9877(97)90258-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Does dehydroepiandrosterone act as an adrenal hormone in humans to maintain cortisol homeostasis by serving as a cortisol antagonist? If so, dehydroepiandrosterone might block the development of the diverse pathological processes potentiated by prolonged cortisol hyperactivity. And the plasma concentrations of total dehydroepiandrosterone and total cortisol, expressed as a C/D ratio, would have an important influence on the development of age-related pathology in diseases exacerbated by cortisol hyperactivity. Several major age-related diseases, designated as cortisol-potentiated diseases, belong in this category. The C/D concept predicts, other factors being equal, that the risk of initiation and progression of these diseases at all ages is directly related to the C/D ratio, individuals with elevated C/D ratios being at high risk.
引用
收藏
页码:85 / 91
页数:7
相关论文
共 41 条
[11]   REGULATION OF MURINE LYMPHOKINE PRODUCTION INVIVO .2. DEHYDROEPIANDROSTERONE IS A NATURAL ENHANCER OF INTERLEUKIN-2 SYNTHESIS BY HELPER T-CELLS [J].
DAYNES, RA ;
DUDLEY, DJ ;
ARANEO, BA .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (04) :793-802
[12]   PATTERN OF PLASMA DEHYDROEPIANDROSTERONE SULFATE LEVELS IN HUMANS FROM BIRTH TO ADULTHOOD - EVIDENCE FOR TESTICULAR PRODUCTION [J].
DEPERETTI, E ;
FOREST, MG .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1978, 47 (03) :572-577
[13]  
FAUCI AS, 1979, GLUCOCORTICOID HORMO, P449
[14]  
FRIEDMAN M, 1966, LANCET, V2, P291
[15]   MODULATION OF GROWTH, DIFFERENTIATION AND CARCINOGENESIS BY DEHYDROEPIANDROSTERONE [J].
GORDON, GB ;
SHANTZ, LM ;
TALALAY, P .
ADVANCES IN ENZYME REGULATION, 1987, 26 :355-382
[16]  
KALIMI M, 1990, BIOL ROLE DEHYDROEPI
[17]  
KANNAN CR, 1988, ADRENAL GLAND, P97
[18]   BASAL CORTISOL-LEVELS AND COGNITIVE DEFICITS IN HUMAN AGING [J].
LUPIEN, S ;
LECOURS, AR ;
LUSSIER, I ;
SCHWARTZ, G ;
NAIR, NPV ;
MEANEY, MJ .
JOURNAL OF NEUROSCIENCE, 1994, 14 (05) :2893-2903
[19]  
MAY M, 1990, LIFE SCI, V46, P1627
[20]   HERITABILITY OF VARIATION OF PLASMA-CORTISOL LEVELS [J].
MEIKLE, AW ;
STRINGHAM, JD ;
WOODWARD, MG ;
BISHOP, DT .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1988, 37 (06) :514-517