Roles of heparan-sulphate glycosaminoglycans in cancer

被引：540

作者：

Sasisekharan, R

Shriver, Z

Venkataraman, G

Narayanasami, U

机构：

[1] MIT, Biol Engn Div, Cambridge, MA 02139 USA

[2] MIT, Ctr Biomed Engn, Cambridge, MA 02139 USA

[3] Tufts Univ, Sch Med, New England Med Ctr, Div Hematol & Oncol, Boston, MA 02111 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc842

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell-surface/extracellular-matrix heparan-sulphate glycosaminoglycans (HSGAGs) are complex polysaccharides that are ubiquitous in nature, and that regulate several aspects of cancer biology, including tumorigenesis, tumour progression and metastasis. Recently gained insights into the structure of HSGAGs have extended our understanding of their role in the oncogenic process. At present, clinical trials are examining the anticancer properties of exogenous highly sulphated HSGAGs, including heparin and low-molecular-weight heparins, in addition to small oligosaccharide heparin mimetics. Combined with our more intricate understanding of HSGAG structure, this emerging structure-activity approach opens exciting avenues for the generation of polysaccharide-based anticancer therapeutics.

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收藏

页码：521 / 528

页数：8

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