Chemoselective C(sp3)-H bond activation for the preparation of condensed N-heterocycles

被引:56
作者
Ren, Hongjun [1 ]
Li, Zhuo [1 ]
Knochel, Paul [1 ]
机构
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
关键词
C-H activation; N-heterocycles; palladium; pyrroles; successive reactions;
D O I
10.1002/asia.200600398
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Condensed N-heterocycles were prepared by using C-H activation reactions catalyzed by Pd(OAc)(2) (5 mol %) and (p-tolyl)(3)P (10 mol %). The key step of these ring closures is chemoselective intramolecular C-H activation of the methyl group at position 2 of the pyrrole ring. Functionalized 9H-pyrrolo[1,2-a]indoles and pyrrolo [1,2-f] phenanthridine derivatives were prepared in good yields. The preparation of some complex N-heterocycles by using successive reactions is also described.
引用
收藏
页码:416 / 433
页数:18
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