Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system

被引：149

作者：

Haitina, Tatjana ^{[1
]}

Lindblom, Jonas ^{[1
]}

Renstrom, Thomas ^{[1
]}

Fredriksson, Robert ^{[1
]}

机构：

[1] Uppsala Univ, Dept Neurosci, Pharmacol Unit, BMC, SE-75124 Uppsala, Sweden

来源：

GENOMICS | 2006年 / 88卷 / 06期

关键词：

mitochondrial transporter; SLC; human; rat; mouse; expression;

D O I：

10.1016/j.ygeno.2006.06.016

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Members of the solute carrier family 25 (SLC25) are known to transport molecules over the mitochondrial membrane. In this paper we present 14 novel members of SLC25 family in human. These were provided with following gene symbols by the HGNC: SLC25A32, SLC25A33, SLC25A34. SLC25A35, SLC25A37, SLC25A38, SLC25A39, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, and SLC25A46. We also identified the orthologues for these genes in rat and mouse. Moreover, we found yeast orthologues for 9 of these genes and show that the predicted substrate binding residues are highly conserved in the human and yeast proteins. We performed a comprehensive tissue localization study for 9 of these genes on a panel of 30 rat tissues with quantitative real-time polymerse chain reaction. We detected their mRNA in a wide number of tissues, both in brain and in periphery. This study provides an overall roadmap of the repertoire of the SLC25 family in mammals. showing that there are at least 46 genes in the human genome coding for mitochondrial transporters. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：779 / 790

页数：12

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