Protein degradation: The ins and outs of the matter

被引：21

作者：

Cresswell, P

Hughes, EA

机构：

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(06)00279-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In eukaryotic cells, nascent membrane or secretory proteins are translocated into the endoplasmic reticulum through the Sec61p translocation channel; recent evidence suggests that, if they fail to achieve a native conformation, they are translocated back into the cytosol by the same route and degraded by the proteasome.

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页码：R552 / R555

页数：4

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