Nox proteins in signal transduction

被引：677

作者：

Brown, David I. ^{[1
]}

Griendling, Kathy K. ^{[1
]}

机构：

[1] Emory Univ, Div Cardiol, Dept Med, Atlanta, GA 30322 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2009年 / 47卷 / 09期

基金：

美国国家卫生研究院;

关键词：

NADPH oxidase; Nox; Nox1; Nox2; Nox3; Nox4; Nox5; Duox1; Duox2; ROS; Superoxide; Hydrogen peroxide; Signal transduction; Signaling; Redox; SMOOTH-MUSCLE-CELLS; SUPEROXIDE-GENERATING OXIDASE; FAMILY NADPH OXIDASES; RECEPTOR-INTERACTING PROTEIN; OXYGEN SPECIES GENERATION; FACTOR-INDUCED MIGRATION; AKT/PROTEIN KINASE-B; SMALL GTPASE RAC; REACTIVE OXYGEN; ANGIOTENSIN-II;

D O I：

10.1016/j.freeradbiomed.2009.07.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The NADPH oxidase (Nox) family of superoxide (O-2(center dot-)) and hydrogen peroxide (H2O2)-producing proteins has emerged as an important source of reactive oxygen species (ROS) in signal transduction. ROS produced by Nox proteins Nox1-5 and Duox1/2 are now recognized to play essential roles in the physiology of the brain, the immune system, the vasculature, and the digestive tract as well as in hormone synthesis. Nox-derived ROS have been implicated in regulation of cytoskeletal remodeling, gene expression. proliferation, differentiation, migration, and cell death. These processes are tightly controlled and reversible. In this review, we will discuss recent literature on Nox protein tissue distribution, subcellular localization, activation, and the resulting signal transduction mechanisms. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1239 / 1253

页数：15

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