A systematic regional study of dopamine and dopamine-derived salsolinol and norsalsolinol levels in human brain areas

被引：38

作者：

Musshoff, F

Schmidt, P

Dettmeyer, R

Priemer, F

Wittig, H

Madea, B

机构：

[1] Univ Bonn, Inst Med Legale, D-53111 Bonn, Germany

[2] Univ Munich, Inst Med Legale, D-80337 Munich, Germany

[3] Otto Von Guericke Univ, Inst Med Legale, D-39120 Magdeburg, Germany

来源：

FORENSIC SCIENCE INTERNATIONAL | 1999年 / 105卷 / 01期

关键词：

salsolinol; norsalsolinol; dopamine; tetrahydroisoquinolines; human brain; HPLC; alcoholism; regional distribution;

D O I：

10.1016/S0379-0738(99)00110-3

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Dopamine and the dopamine-derived tetrahydroisoquinoline alkaloids salsolinol and norsalsolinol were measured by high-performance liquid chromatography with electrochemical detection in 15 regions of the human brain. The regional distribution of dopamine in 32 brains was similar to previous reports with highest concentrations in the basal ganglia, especially in the striatum, followed by the substantia nigra and the hypothalamus. Significant amounts of salsolinol and norsalsolinol were only found in these dopamine-rich areas, whereas in the other regions no alkaloids were detected. These findings suggest that the concentration of the substrate dopamine may determine the alkaloid level during in vivo formation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 11

页数：11

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[1] POSTMORTEM DISTRIBUTION OF DOPAMINE AND HOMOVANILLIC-ACID IN HUMAN-BRAIN, VARIATIONS RELATED TO AGE, AND A REVIEW OF THE LITERATURE [J].