Lack of association between hypermutation and antibiotic resistance development in Pseudomonas aeruginosa isolates from intensive care unit patients

被引：53

作者：

Gutiérrez, O ^{[1
]}

Juan, C ^{[1
]}

Pérez, JL ^{[1
]}

Oliver, A ^{[1
]}

机构：

[1] Hosp Son Dureta, Microbiol Serv, Palma de Mallorca 07014, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 09期

关键词：

D O I：

10.1128/AAC.48.9.3573-3575.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational antibiotic resistance development is a frequent outcome, the prevalence of hypermutable strains is low (found in isolates from only 1 of 103 patients) and there is no evidence of coselection of the hypermutable and antibiotic resistance phenotypes.

引用

页码：3573 / 3575

页数：3

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