Early prediction of changes in weight during six weeks of treatment with antidepressants

被引：33

作者：

Himmerich, H ^{[1
]}

Schuld, A ^{[1
]}

Haack, M ^{[1
]}

Kaufmann, C ^{[1
]}

Pollmächer, T ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2004年 / 38卷 / 05期

关键词：

weight gain; prediction; antidepressants; leptin; TNF;

D O I：

10.1016/j.jpsychires.2004.02.002

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Weight gain is a frequent and important side effect of psychotropic treatment. We sought to determine weight change predictors during treatment with antidepressant drugs. In 24 patients weight, plasma levels of leptin, tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptors were determined longitudinally and a multiple linear regression analysis was used to predict weight change from baseline to the sixth week of treatment. Changes of weight during the first week of treatment, but no other parameter, strongly predicted weight change until endpoint (adjusted R-2 = 0.68, F = 50.45, df = 1,23, p < 0.001). Very early changes in weight during treatment with psychotropic drugs might be a simple and clinically useful predictor of future weight development. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：485 / 489

页数：5

共 24 条

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