Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research

被引：1007

作者：

Nater, U. M. ^{[1
]}

Rohleder, N. ^{[2
]}

机构：

[1] Univ Zurich, Inst Psychol, Dept Clin Psychol & Psychotherapy, CH-8050 Zurich, Switzerland

[2] Brandeis Univ, Dept Psychol, Waltham, MA 02254 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 2009年 / 34卷 / 04期

关键词：

Alpha-amylase; Stress; Biomarker; Sympathetic nervous system; RAT PAROTID SLICES; POSTTRAUMATIC-STRESS-DISORDER; MENTAL ARITHMETIC STRESS; PSYCHOSOCIAL STRESS; PSYCHOLOGICAL STRESS; ADRENERGIC ACTIVITY; CORTISOL RESPONSES; ENZYME-SECRETION; PROTEIN-LEVELS; YOUNG-WOMEN;

D O I：

10.1016/j.psyneuen.2009.01.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Development of new biomarkers is a constantly evolving field of research endeavor in psychoneuroendocrinology. Salivary biomarkers have received special attention since they are readily accessible and easily obtained. Salivary alpha-amylase (sAA) has been proposed as a sensitive biomarker for stress-related changes in the body that reflect the activity of the sympathetic nervous system (SNS), and a growing body of research is accumulating to support the validity and reliability of this parameter. However, questions remain to be answered before sAA can be accepted as an index of SNS activity. This review describes sAA as an emerging biomarker for stress and provides an overview of the current literature on stress-related alterations in sAA. It critically discusses how sAA might reflect changes in the autonomic nervous system. Finally, current and future fields for the application of sAA measurement are outlined. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：486 / 496

页数：11

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