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Neuritic plaques in the Lewy body variant of Alzheimer disease lack paired helical filaments

被引：8
作者：
Samuel, W
Crowder, R
Hofstetter, CR
Hansen, L
机构：
[1] VET ADM MED CTR,DEPT NEUROL,LA JOLLA,CA 92093
[2] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,SAN DIEGO,CA 92103
[3] UNIV CALIF SAN DIEGO,DEPT PATHOL,SAN DIEGO,CA 92103
来源：
NEUROSCIENCE LETTERS | 1997年 / 223卷 / 02期
关键词：
Lewy body disease; Alzheimer disease; plaques; paired helical filaments;
D O I：
10.1016/S0304-3940(97)13404-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The Lewy body variant of Alzheimer disease (LBV) is a distinct category of dementia which, unlike pure diffuse Lewy body disease (DLBD), meets clinical and neuropathologic criteria for Alzheimer disease (AD) but differs from pure AD in having a neocortical predominance of diffuse and neuritic plaques (NP), with very few neurofibrillary tangles (NFT). We investigated the immunoreactivity of NP with a monoclonal antibody against paired helical filaments (PHF) composed of phosphorylated microtubule associated protein tau. With routine thioflavin-S preparations, 12 LBV and 14 AD cases had similar numbers of NP, but the LBV had significantly (P < 0.05) fewer NFT per microscopic field in the midfrontal cortex. Among subjects with midfrontal NFT, 81-84% of NP in AD and LBV were anti-PHF positive. Among subjects without midfrontal NFT, 52% of NP in AD but only 12% of NP in LBV cases were anti-PHF positive (P < 0.05). LBV differs from AD in that its NP generally do not contain PHF, unless they are accompanied by neocortical NFT. (C) 1997 Elsevier Science Ireland Ltd.
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页码：73 / 76
页数：4
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