Novel strategies to delineate matrix metalloproteinase (MMP) - Substrate relationships and identify targets to block MMP activity

被引：13

作者：

Lindsey, M. L. ^{[1
]}

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Med, Div Cardiol, San Antonio, TX 78229 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 11期

关键词：

matrix metalloproteinases; extracellular matrix; MMP inhibitors; mechanism-based inhibition; proteomics; remodeling; fibrosis;

D O I：

10.2174/138955706778742777

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Adverse extracellular matrix (ECM) remodeling contributes to fibrotic disorders in the kidney, lung, and heart. Matrix metalloproteinases (MMPs) are key enzymes regulating ECM turnover, and MMP inhibition attenuates remodeling. Recent technological developments allow MMP-substrate relationships to be identified and explored as novel therapeutic targets. This review summarizes current and novel strategies to block MMP activity.

引用

页码：1243 / 1248

页数：6

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