The art and design of genetic screens: Filamentous fungi

被引：57

作者：

Casselton, L

Zolan, M

机构：

[1] Univ Oxford, Dept Plant Sci, Oxford OX1 3RB, England

[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 09期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrg889

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the 1940s, screens for metabolic mutants of the filamentous fungus Neurospora crassa established the fundamental, one-to-one relationship between a gene and a specific protein, and also established fungi as important genetic organisms. Today, a wide range of filamentous species, which represents a billion years of evolutionary divergence, is used for experimental studies. The developmental complexity of these fungi sets them apart from unicellular yeasts, and allows the development of new screens that enable us to address biological questions that are relevant to all eukaryotes.

引用

页码：683 / 697

页数：15

共 116 条

[51]

Kelly KO, 2000, GENETICS, V156, P617

[52]

LECHEVANTON L, 1991, MORE GENE MANIPULATI, P291

[53]

LESLIE JF, 1985, GENETICS, V111, P759

[54] Homolog pairing and meiotic progression in Coprinus cinereus [J].