The effects of palm tocotrienol on metabolic syndrome and bone loss in male rats induced by high-carbohydrate high-fat diet

被引：30

作者：

Wong, Sok Kuan ^{[1
]}

Chin, Kok-Yong ^{[1
]}

Suhaimi, Farihah H. J. ^{[2
]}

Ahmad, Faints ^{[2
]}

Ima-Nirwana, Soelaiman ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaakob Latif, Kuala Lumpur 56000, Malaysia

[2] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Jalan Yaakob Latif, Kuala Lumpur 56000, Malaysia

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 44卷

关键词：

Cholesterol; Obesity; Glucose; Triglycerides; Osteoporosis; Vitamin E; VITAMIN-E; INFLAMMATION; OSTEOPOROSIS; PARAMETERS; TOCOPHEROL; RISK;

D O I：

10.1016/j.jff.2018.03.022

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Inflammation is a possible mediator of the relationship between metabolic syndrome (MetS) and osteoporosis. Palm tocotrienol, an anti-inflammatory agent, has been reported to exert beneficial effects for the treatment of MetS and osteoporosis individually. This study aimed to investigate the potential role of palm tocotrienol in preventing both MetS and bone loss in male rats via alleviating the inflammatory response. In this study, MetS was established in the rats fed with HCHF diet. This was accompanied by bone loss and elevated pro-inflammatory cytokine levels. Supplementation of palm tocotrienol improved MetS parameters, trabecular bone microstructure, bone strength, and reduced pro-inflammatory cytokines in the HCHF rats. A dose-dependent effect of palm tocotrienol was also observed in preventing MetS conditions. In conclusion, palm tocotrienol prevents both MetS and bone loss, possibly through its anti-inflammatory properties.

引用

页码：246 / 254

页数：9

共 49 条

[1]

Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases [J].

Aggarwal, Bharat B. ;

Sundaram, Chitra ;

Prasad, Seema ;

Kannappan, Ramaswamy .

BIOCHEMICAL PHARMACOLOGY, 2010, 80 (11) :1613-1631

[2]

Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone [J].

Ahmad, NS ;

Khalid, BAK ;

Luke, DA ;

Nirwana, SI .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2005, 32 (09) :761-770

[3]

Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].

Alberti, K. G. M. M. ;

Eckel, Robert H. ;

Grundy, Scott M. ;

Zimmet, Paul Z. ;

Cleeman, James I. ;

Donato, Karen A. ;

Fruchart, Jean-Charles ;

James, W. Philip T. ;

Loria, Catherine M. ;

Smith, Sidney C., Jr. .

CIRCULATION, 2009, 120 (16) :1640-1645

[4]

Causes, consequences, and treatment of osteoporosis in men [J].

Banu, Jameela .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2013, 7 :849-860

[5]

Budin SB, 2009, CLINICS, V64, P235

[6]

Dietary factors and low-grade inflammation in relation to overweight and obesity [J].

Calder, Philip C. ;

Ahluwalia, Namanjeet ;

Brouns, Fred ;

Buetler, Timo ;

Clement, Karine ;

Cunningham, Karen ;

Esposito, Katherine ;

Jonsson, Lena S. ;

Kolb, Hubert ;

Lansink, Mirian ;

Marcos, Ascension ;

Margioris, Andrew ;

Matusheski, Nathan ;

Nordmann, Herve ;

O'Brien, John ;

Pugliese, Giuseppe ;

Rizkalla, Salwa ;

Schalkwijk, Casper ;

Tuomilehto, Jaakko ;

Waernberg, Julia ;

Watzl, Bernhard ;

Winklhofer-Roob, Brigitte M. .

BRITISH JOURNAL OF NUTRITION, 2011, 106 :S1-S78

[7]

The metabolic syndrome: prevalence in worldwide populations [J].

Cameron, AJ ;

Shaw, JE ;

Zimmet, PZ .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2004, 33 (02) :351-+

[8]

Chin K. Y, 2016, NUTRIENTS, V8

[9]

The biological effects of tocotrienol on bone: a review on evidence from rodent models [J].

Chin, Kok-Yong ;

Ima-Nirwana, Soelaiman .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2015, 9 :2049-2060

[10]

The association between bone health indicated by calcaneal quantitative ultrasound and metabolic syndrome in Malaysian men [J].

Chin K.-Y. ;

Ima-Nirwana S. ;

Mohamed I.N. ;

Ahmad F. ;

Mohd Ramli E.S. ;

Aminuddin A. ;

Wan Ngah W.Z. .

Journal of Diabetes & Metabolic Disorders, 14 (1)

← 1 2 3 4 5 →