Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities

被引：20

作者：

Akamatsu, Masao

Fujimoto, Yukarl

Kataoka, Mikayo

Suda, Yasuo

Kusumoto, Shoichi

Fukase, Koichi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Chem, Toyonaka, Osaka 5600043, Japan

[2] Kagoshima Univ, Grad Sch Sci & Engn, Dept Nanostruct & Adv Mat, Kagoshima 8900065, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 19期

基金：

日本学术振兴会;

关键词：

innate immunity; lipid A; cytokine induction; IL-6; endotoxin;

D O I：

10.1016/j.bmc.2006.05.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For elucidation of the structural and conformational requirements on the endotoxic and antagonistic activity of lipid A derivatives, we designed and synthesized lipid A analogues containing acidic amino acid residues in place of the non-reducing end phosphorylated glucosamine. Definite switching of the endotoxic or antagonistic activity was observed depending on the difference of the acidic groups (phosphoric acid or carboxylic acid) in the lipid A analogues. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6759 / 6777

页数：19

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