Naturally occurring extended-spectrum cephalosporinases in Escherichia coli

被引：54

作者：

Mammeri, Hedi ^{[1
]}

Poirel, Laurent ^{[1
]}

Fortineau, Nicolas ^{[1
]}

Nordmann, Patrice ^{[1
]}

机构：

[1] Univ Paris Sud, Serv Bacteriol Virol, Hop Bicetre, Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 07期

关键词：

D O I：

10.1128/AAC.01633-05

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that GIn287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.

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页码：2573 / 2576

页数：4

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