Conversion of a C-20 2,3-oxidosqualene analog to tricyclic structures with a five-membered C-ring by lanosterol synthase. Further evidence for a C-ring expansion step in sterol biosynthesis

被引：41

作者：

Corey, EJ

Cheng, HM

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 16期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(96)00366-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lanosterol synthase converts the truncated analog 6 of 2,3-oxidosqualene (1) into three tricyclic products, 7, 8 and 9, each of which contains a five-membered C-ring. The results are in accord with expectations based on previous work indicating that the six-membered C-ring of sterols is formed via a five -membered predecessor. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：2709 / 2712

页数：4

共 12 条

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