A SHORT AND CONVERGENT ENANTIOSELECTIVE SYNTHESIS OF (3S)-2,3-OXIDOSQUALENE

被引：62

作者：

COREY, EJ

NOE, MC

SHIEH, WC

机构：

[1] Department of Chemistry, Harvard University, Cambridge

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)61710-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A very useful synthesis of (3S)-2,3-oxidosqualene from geraniol, farnesol and E-1-bromo-4-chloro-3-methyl-2-butene is described which makes use of enantioselective and catalytic dihydroxylation of geranyl acetate and two E-stereospecific allylic coupling reactions mediated by E-prenylbarium reagents.

引用

页码：5995 / 5998

页数：4

共 27 条

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