Nanomedicine as a future therapeutic approach for Hepatitis C virus

被引：37

作者：

Abd Ellah, Noura H. ^{[1
,2
]}

Tawfeek, Hesham M. ^{[3
,4
]}

John, James ^{[5
]}

Hetta, Helal F. ^{[6
,7
]}

机构：

[1] Univ Cincinnati, James L Winkle Coll Pharm, Div Pharmaceut Sci, Med Sci Bldg, Cincinnati, OH 45267 USA

[2] Assiut Univ, Fac Pharm, Dept Pharmaceut, Assiut 71526, Egypt

[3] Assiut Univ, Dept Ind Pharm, Fac Pharm, Assiut 71526, Egypt

[4] Mutah Univ, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Al Karak, Jordan

[5] Sri Ramachandra Univ, Cent Res Facil, Sri Ramachandra Inst Higher Educ & Res, Chennai, Tamil Nadu, India

[6] Assiut Univ, Fac Med, Dept Med Microbiol & Immunol, Assiut 71526, Egypt

[7] Univ Cincinnati, Coll Med, Dept Internal Med, Cincinnati, OH 45267 USA

来源：

NANOMEDICINE | 2019年 / 14卷 / 11期

关键词：

anti-HCV; anti-hepatitis C virus; antiviral drugs; hepatitis C virus; nanomedicine; nanoparticles; REGULATORY T-CELLS; ANTIVIRAL PEPTIDE NANOCOMPLEXES; ADAPTIVE IMMUNE-RESPONSES; DRUG-DELIVERY; CORE ANTIGEN; IN-VITRO; NEUTRALIZING ANTIBODIES; OXIDE NANOPARTICLES; GOLD NANOPARTICLES; LIVER INFLAMMATION;

D O I：

10.2217/nnm-2018-0348

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Hepatitis C virus (HCV) is not easily cleared from thehuman body and in most cases turned into chronic infection. This chronicity is a major cause of liver damage, cirrhosis and hepatocellular carcinoma. Therefore, immediate detection and treatment of HCV guarantees eradication of the virus and prevention of chronicity complications. Since discovery of HCV in 1989, several emerging treatments were developed such aspolyethylene glycol(PEG)-ylated interferon/ribavirin, direct acting antivirals and host targeting antivirals. Despite the progress in anti-HCV therapy, there is still a pressing need of new approaches for affordable and effective drug delivery systems using nanomedicine. In this review, the contribution of nanoparticles as a promising delivery system for HCV immunizing, diagnostic and therapeutic agents are discussed.

引用

页码：1471 / 1491

页数：21

共 140 条

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