A nonidentifiability aspect of the two-stage model of carcinogenesis

被引：35

作者：

Hanin, LG ^{[1
]}

Yakovlev, AY ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT STAT,COLUMBUS,OH 43210

来源：

RISK ANALYSIS | 1996年 / 16卷 / 05期

关键词：

carcinogenesis; latent time distribution; two-stage model; nonidentifiability;

D O I：

10.1111/j.1539-6924.1996.tb00819.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This paper discusses identifiability of the two-stage birth-death-mutation model of carcinogenesis. It is shown that the homogeneous version of the model is nonidentifiable; the same is all the more evident for its nonhomogeneous versions. This result implies that the model parameters cannot be uniquely estimated from time-to-tumor observations.

引用

页码：711 / 715

页数：5

共 10 条

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Cox D.R., 1980, POINT PROCESSES

[2]

HEIDENRICH W, 1996, IN PRESS RAD ENV BIO

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