Murine B7-H3 is a negative regulator of T cells

被引：294

作者：

Prasad, DVR ^{[1
]}

Nguyen, T ^{[1
]}

Li, ZX ^{[1
]}

Yang, Y ^{[1
]}

Duong, J ^{[1
]}

Wang, Y ^{[1
]}

Dong, C ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Sch Med, Seattle, WA 98195 USA

来源：

JOURNAL OF IMMUNOLOGY | 2004年 / 173卷 / 04期

关键词：

D O I：

10.4049/jimmunol.173.4.2500

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. B7-H3 is a novel B7-like molecule with a putative receptor on activated T cells. Human B7-H3 was first described as a positive costimulator, most potently inducing IFN-gamma production and cellular immunity. In this study we examined the expression and function of mouse B7-H3. B7-H3 is mostly expressed on professional APCs; its expression on dendritic cells appears to be up-regulated by LPS. In contrast to human B7-H3, we found that mouse B7-H3 protein inhibited T cell activation and effector cytokine production. An antagonistic mAb to B7-H3 enhanced T cell proliferation in vitro and led to exacerbated experimental autoinumme encephalomyelitis in vivo. Therefore, mouse B7-H3 serves as a negative regulator of T cell activation and function.

引用

页码：2500 / 2506

页数：7

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